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Oral Medications for the Management of Acute Migraine Headache in the Emergency Department

Oral v. Parenteral Medications for the Emergency Management of Acute Migraine: a Pilot Randomized Control Trial

Sponsor
Health Sciences North Research Institute (Academic or other)
Conditions
Acute Migraine Headache
Interventions
Oral metoclopramide and ibuprofen; Intravenous metoclopramide and ketorolac
Ages
adults
Registry
NCT05983354

Full record on ClinicalTrials.gov

From the registry

The goal of this pilot randomized control trial is to assess the feasibility of our patient recruitment and data collection strategy ahead of a full scale RCT investigating the efficacy of oral v. parenteral medications in the management of acute migraine headaches in the emergency department. Patients will be randomly assigned to receive either (A) standard medical therapy for the treatment of acute migraine headache (metoclopramide and ketorolac IV) and oral placebo or (B) oral metoclopramide and ibuprofen with normal saline IV. Primary outcome measures are recruitment rate and improvement in pain score at 60 minutes from medication administration.

Primary outcomes

  • Recruitment rate
  • Pain relief

History

  1. Last registry update

  2. Primary completion

  3. Registered

  4. Started