Papers by Tian Hao

6 results

  1. Advanced Science

    Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice

    The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic…The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.

    Experiments in miceHuntington's disease