Biochemical Pharmacology
Blocking Src kinase reduces neuroinflammation by activating microglial mitophagy in mice
Inhibiting the kinase reduced p62 UFMylation to promote ubiquitination and mitochondrial clearance, alleviating cognitive deficits in mice.Inhibiting the kinase reduced p62 UFMylation to promote ubiquitination and mitochondrial clearance, alleviating cognitive deficits in mice.
Experiments in miceMitophagy