bioRxiv
Deleting the mechanosensitive channel Piezo1 prevents gut motility decline in aging mice
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.
Preprint: experiments in micePIEZO1