Research Square · Nov 10, 2026

Do Statins improve Periodontal Status? Plaque Index, Community Periodontal Index and Salivary Alpha-amylase Enzyme in A case- control study

By Abdolali B, Kakavand H, Babaei A et al.

Periodontal disease is a chronic inflammatory condition prevalent among adults. Given the anti-inflammatory properties of statins and their potential relation with periodontal disease, this study aims to investigate the effects of statins on the plaque index (PI), community periodontal index (CPI), and salivary alpha-amylase enzyme. This case-control study included 140 patients into three major groups: a control group, a moderate-dose statin and a high-dose statin group (atorvastatin and rosuvastatin). PI and CPI indices were assessed for all participants. Saliva samples were collected to measure the activity of salivary alpha-amylase enzyme and total protein using a spectrophotometric method. Data were analyzed using SPSS version 27, applying Chi-square, Kruskal-Wallis and Univariate statistical tests. Significant differences in PI, CPI and salivary enzyme alpha-amylase levels were observed among the groups (P < 0.05). However, total protein levels did not differ significantly. No significant relationships were found between PI and CPI and salivary alpha-amylase enzyme and variables such as sex, age, oral health behaviors or duration of drug use. The findings suggest that statins are capable of affecting periodontal indices and salivary enzyme activity. Further research is recommended to confirm these effects. In Addition, no relationship between higher statin dose intakes and periodontal health improvement were observed.

doi.org/10.21203/rs.3.rs-11410562/v1Open accessInterventions