Research Square
Semaglutide and Suicidality in Adults with Overweight or Obesity: A Bayesian Meta-Analysis of Randomized Trials
By Félix Julián Campos García, Jose Luis Millet-Herrera, Ermilo Echeverria-Ortegon, Jorge-Santiago Rivera-Lavalle, Hugo Laviada-Molina
Preprint: meta-analysis of randomised trialsInterventions
Preregistered CRD420251059430
Abstract
Background Concerns have been raised regarding a potential association between glucagon-like peptide-1 receptor agonists and suicidality. Because suicidal outcomes are exceptionally uncommon in randomized trials, conventional meta-analytic estimates may be unstable and may exclude trials with no events.
The paper
Universidad Marista de Mérida; Universidad Marista
Research Square, 10 Sep 2026, CC BY, Preprint, not peer-reviewed
