Cell · Oct 29, 2026

Calorie restriction uncouples mutation rate from lifespan

By Schumacher B

In this issue of Cell, Grońska-Pęski et al. examine how calorie restriction (CR) affects DNA mutation rates. While CR lowers the accumulation of mutations, this effect does not scale with the degree of lifespan extension. Their work raises important new questions about how CR impacts the causal mechanisms of aging.

doi.org/10.1016/j.cell.2026.09.038PubMed 42956715Interventions