Bioscience · Jun 26, 2025

The Geroscience Perspective on One Health

By Farrelly C

The One Health concept has been invoked to foster collaborations at the intersection of human, animal, and environmental health to address zoonotic disease risk. But the One Health concept is also helpful in framing and addressing the public health imperative to prevent and delay the onset of the chronic diseases of late life, to extend healthy life expectancy in ways that are sustainable and beneficial to animal and environmental health. This is an urgent global health imperative because healthy life expectancy is not increasing at the same pace as life expectancy, leading to more years being lived in poor health. This Forum article advances the Geroscience Perspective on One Health, a framework that draws attention to the interdependence of healthy human aging and animal and environmental health by emphasizing the importance of pursuing nonpharmacological (environmental and lifestyle) and potential pharmacological (gerotherapeutics) interventions to increase healthspan.

doi.org/10.1093/biosci/biaf080Open accessPubMed 42936776Interventions