Public Health Nursing · Oct 22, 2026

Fatigue Interventions in Patients With Chronic Obstructive Pulmonary Disease and Heart Diseases: A Systematic Review and Meta-Analysis

By Holmgaard FG, Raunkiaer M, Hansen RS et al.

BACKGROUND: Fatigue is a significant yet under-addressed symptom in chronic obstructive pulmonary disease (COPD) and heart diseases, impairing quality of life. This systematic review aims to investigate the effectiveness of rehabilitation interventions, including exercise and psychosocial support, in managing fatigue in COPD, ischemic heart disease, and heart failure, providing evidence to guide clinical practice. METHODS: This systematic review is registered in PROSPERO and follows the PRISMA 2020 guidelines. A comprehensive literature search was conducted in PubMed, EMBASE, MEDLINE, CINAHL, and PsycINFO. RESULTS: The pooled meta-analysis with all studies had an overall mean difference of -11.93 [-15.63; -8.24]. Physical activity had the largest effect (-17.01 [-24.40; -9.61]), while combined psychosocial and physical activity interventions were insignificant. Results remained unchanged after sensitivity analysis. CONCLUSION: Meta-analyses highlight the effectiveness of non-pharmacological rehabilitation interventions, particularly physical activity, in managing fatigue. Psychosocial interventions show potential but may be less effective. Future research should optimize strategies, explore fatigue mechanisms, and address patient needs to improve intervention efficacy.

doi.org/10.1111/phn.70199 Open access PubMed 42910776 Interventions