Science Advances

A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders

By Justin Y. Lee, Chi Zhu, Melissa A. Boldridge, Anders M. Näär

Experiments in animalsInterventions

The paper

Justin Y. Lee, Chi Zhu, Melissa A. Boldridge, Anders M. Näär

University of California, Berkeley

Science Advances, 21 Aug 2026

doi.org/10.1126/sciadv.aed3119 PubMed 42627907

Cell Metabolism8 Oct 2026
A triple-target drug cut body weight by up to 19.7% in a trial
The New England Journal of Medicine4 Oct 2026
Survodutide reduces weight in adults with diabetes and obesity
Lancet4 Oct 2026
Retatrutide reduces bodyweight in obesity and type 2 diabetes
The New England Journal of Medicine4 Oct 2026
Retatrutide reduces weight and pain in adults with obesity