Archives of Physiology and Biochemistry · Apr 13, 2026

The role of Klotho protein in delaying cellular ageing through exercise intervention: SA - β - Gal activity and age-related metabolism

By Xie J, Luo S

BACKGROUND: Cellular ageing is closely related to various age-related diseases, and Klotho protein, as an anti-ageing related factor, plays an important role in delaying ageing by regulating cellular function and metabolism. PURPOSE: This study aims to explore the role of Klotho protein in exercise intervention and its relationship with age-related metabolism. METHODS: Study the effects of exercise intervention on serum Klotho protein levels, Klotho gene methylation status, ageing related β - galactosidase (SA - β - Gal) activity, and ageing metabolic indicators, revealing the molecular mechanism of exercise delaying cellular ageing. The experiment was divided into a control group and an exercise intervention group, with an intervention period of 12 weeks. RESULTS: Exercise intervention significantly improved oxidative stress indicators and blood lipid metabolism. CONCLUSION: Exercise intervention delays cellular ageing by upregulating serum Klotho protein levels and reducing gene methylation levels, inhibiting SA - β - Gal activity, improving oxidative stress and lipid metabolism.

doi.org/10.1080/13813455.2026.2657414PubMed 41968926Interventions