Oncoimmunology · Apr 9, 2026

Restoring dendritic cell migration: a gut reaction to boost vaccine efficacy in aging

By Zhao L, Kepp O, Kroemer G et al.

Aging impairs vaccine responses. Dai et al. reported that defective cDC2 migration in immunized old mice, diminishing humoral and cellular immunity. Oral yeast-derived nanoparticles restore DC migration and vaccine efficacy. These findings establish impaired DC migration as a key mechanism of age-related immune decline, introducing a noninvasive strategy to correct immunosenescence.

doi.org/10.1080/2162402x.2026.2657070 Open access PubMed 41957938 Interventions