JCI Insight · Mar 31, 2026
Cycling GLP-1 receptor agonist treatment induces therapeutic resistance and increased adiposity
By Son AJ, Rapp E, Wiezorek A et al.
Stopping and restarting GLP-1 weight-loss drugs in mice made them less effective over time and increased fat gain compared with continuous treatment.
doi.org/10.1172/jci.insight.205174Open accessPubMed 41915442Interventions