European Journal of Preventive Cardiology · Mar 18, 2026

Cardiac rehabilitation against frailty and sarcopenia in older individuals: a literature review

By Fukumoto Y

Frailty and sarcopenia are highly prevalent in older adults with cardiovascular disease (CVD), contributing to reduced functional capacity, increased hospitalization, and poorer quality of life. These syndromes share pathophysiological pathways characterized by chronic low-grade inflammation, hormonal decline, impaired nutrient utilization, oxidative stress, and mitochondrial dysfunction. Together, these processes accelerate muscle mass loss, neuromuscular impairment, and diminished physiological reserve, ultimately pre-disposing patients to disability and adverse outcomes. This review summarizes the interplay between sarcopenia, frailty, and CVD, underscoring the therapeutic role of physical activity and cardiac rehabilitation (CR). Resistance training remains the cornerstone of treatment, with strong evidence for improvements in muscle strength and functional performance, although gains in muscle mass are less robust. Conventional CR programmes, however, may not suit all patients. For example, older adults recovering from transcatheter aortic valve implantation for severe aortic stenosis (AS) frequently experience early mobility limitations. In such cases, adapted interventions, including bodyweight resistance training or electrical muscle stimulation (e.g. belt electrode skeletal muscle electrical stimulation), provide safe and effective muscle activation during the recovery phase. Overcoming barriers to implementation requires personalized, scalable, and multidisciplinary approaches. Further research should refine diagnostic criteria, optimize intervention protocols, and evaluate long-term outcomes. Early, tailored rehabilitation strategies are essential in improving prognosis and preserving quality of life in this vulnerable population.

doi.org/10.1093/eurjpc/zwaf591 Open access PubMed 41849658 Interventions