Research Square · Jan 14, 2026

Partial Freezing Enables Functional Preservation of Kidney Grafts for up to 10 Days

By Uygun K, Taggart M, Hassan M et al.

Kidney transplantation is critically limited by the shortage of available donor organs, exacerbated by the discarding of viable organs due to insufficient allocation time. Here, we demonstrate the application of nature-inspired partial freezing for long-term storage of kidney grafts. We show that, after 10 days of storage, partially frozen swine and human kidneys retain improved function compared to those preserved using traditional static cold storage, as assessed via simulated transplantation.

doi.org/10.21203/rs.3.rs-7820837/v1Open accessPubMed 41646296Interventions