Journal of Arrhythmia · Jan 26, 2026

Percutaneous Left Atrial Appendage Occlusion for Atrial Fibrillation in Cardiac Amyloidosis

By Almakadma AH, Ibrahim R, Pham HN et al.

BACKGROUND: Cardiac amyloidosis (CA) is frequently complicated by atrial fibrillation (AF), yet outcomes after left atrial appendage occlusion (LAAO) in this population remain poorly defined. METHODS: We conducted a retrospective TriNetX study of adults with AF undergoing LAAO, comparing patients with and without CA after 1:1 propensity matching. Outcomes were assessed using Kaplan-Meier analyses and Cox regression. RESULTS: Among 532 matched pairs, mortality and major adverse cardiovascular events were similar between groups, whereas major bleeding was higher in CA (HR 1.90). CONCLUSIONS: LAAO yields comparable ischemic outcomes in CA, though bleeding risk is increased.

doi.org/10.1002/joa3.70274 Open access PubMed 41607868 Interventions