Cureus · Nov 17, 2025

Acute Mesenteric Ischemia as a Severe Complication Associated With Tirzepatide: A Case Report and Safety Alert

By Brooks S, Nafees S, Abdi K et al.

Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist used in the management of type 2 diabetes mellitus. We report a case of acute mesenteric ischemia in a patient following treatment with tirzepatide, highlighting a rare but serious adverse event potentially related to its effects on gastrointestinal motility and vascular perfusion. This case emphasizes the necessity for careful patient selection and close clinical monitoring, especially given the increasing use of this medication outside of formal supervision.

doi.org/10.7759/cureus.97035 Open access PubMed 41416326 Interventions