Frontiers in Physiology · Nov 24, 2025

Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson's disease: a 48-month retrospective cohort study

By Moura M, Ferreira MLV, Speri FD et al.

BACKGROUND: Long-term effects of structured exercise on functional capacity in Parkinson's disease (PD) remain poorly understood. OBJECTIVE: To investigate the impact of a 48-month multicomponent exercise program on mobility, aerobic capacity, and muscle mass in individuals with early-stage PD, and to examine baseline predictors of functional performance. METHODS: Thirty-three patients with PD (Hoehn & Yahr stages 1-2) participated in a supervised, thrice-weekly program including aerobic, resistance, balance, and flexibility exercises. Assessments at baseline and 48 months included the Timed Up and Go (TUG), Six-Minute Walk Test (6MWT), peak oxygen uptake (VO₂peak), and muscle mass. Minimal detectable change (MDC), effect sizes, and linear regressions were computed. RESULTS: After 48 months, TUG time decreased by -3.8 s (95% CI: -5.0 to -2.6; p < 0.001; dz = -1.12) and 6MWT distance increased by +88.8 m (95% CI: 45.1 to 133.0; p < 0.001; dz = 0.72), both exceeding MDC thresholds. VO₂peak (-1.1 mL·kg⁻¹·min⁻¹; p = 0.142) and muscle mass (-0.7 kg; p = 0.068) showed no significant changes. VO₂peak was the sole independent predictor of functional performance at baseline and follow-up, while muscle mass had limited explanatory value. Improvements were observed in both disease stages, with similar effect sizes. CONCLUSION: Long-term engagement in a multicomponent exercise program produces sustained functional improvements exceeding measurement error in mobility among individuals with early-stage PD, independent of changes in aerobic capacity or muscle mass. VO₂peak consistently predicted functional outcomes, highlighting aerobic fitness as a key therapeutic target. These findings support the systematic integration of structured, multicomponent exercise into standard care protocols to preserve mobility and independence in PD.

doi.org/10.3389/fphys.2025.1700510 Open access PubMed 41367391 Interventions