Journal of Nephrology · Sep 3, 2025

Effects of electrical muscle stimulation during hemodialysis in older patients with frailty: a crossover randomized controlled trial

By Suzuki Y, Kamiya K, Hoshi K et al.

BACKGROUND: While electrical muscle stimulation during hemodialysis has been reported to improve physical performance in middle-aged patients, clinical evidence regarding its efficacy in older patients with frailty remains limited. METHODS: In this crossover trial, we randomly assigned 18 older patients (aged ≥ 65 years) with frailty receiving maintenance hemodialysis in a 1:1 ratio to the study intervention. Group 1 underwent electrical muscle stimulation first, followed by a five-week washout period, and then the control session without electrical muscle stimulation. Group 2 received the control session first, followed by the electrical muscle stimulation sessions. Eligible patients had physical frailty defined by a Short Physical Performance Battery (SPPB) score of 4-9 points. Electrical muscle stimulation was conducted for 30-40 min per day, 3 days a week, over 5 weeks, during hemodialysis sessions. The primary outcome was the difference in quadriceps isometric strength before and after the treatment period. RESULTS: Among 18 patients who were randomized, 16 patients were included in the intention-to-treat analysis (median age: 76 years [Q1 to Q3, 72 to 79]; men: 38%; median SPPB: 6 points [Q1 to Q3, 5 to 9]). The median change in quadriceps isometric strength (Q1 to Q3) was 1.5%dry weight (%DW) (0.2 to 4.2) during the electrical muscle stimulation intervention period and - 3.6%DW (- 7.7 to - 1.6) during the control period (P = 0.0027). CONCLUSIONS: Our trial found that intradialytic electrical muscle stimulation was associated with improved quadriceps isometric strength in older patients with frailty, indicating a potential benefit of intradialytic electrical muscle stimulation intervention for physical performance, also in these subjects. TRIAL REGISTRATION: The study was registered in a public trial registry (UMIN-CTR, number: UMIN000032501).

doi.org/10.1007/s40620-025-02383-6 PubMed 40900207 Interventions