Multiple Sclerosis and Related Disorders · May 22, 2025

The effects of dual-task training on inflammatory biomarkers, physical performance, fatigue, and quality of life in patients with multiple sclerosis

By Farajnia S, Rajabi H, Ghaffari M et al.

OBJECTIVE: This study investigates how combined aerobic-cognitive training and aerobic training impact some symptoms of MS. METHODS: Thirty RRMS patients with EDSS≤ 4 were randomly assigned to three groups: Brythonic training, aerobic training, and control. The training groups participated in ten weeks of home-based online training. The Brythonic group performed aerobic movements while reciting motivational words. The aerobic group performed the same movements without cognitive tasks. Interleukin 17 (IL-17), Interleukin 4 (IL-4), and Interleukin 17 to Interleukin 4 ratio (IL-4/IL-17), Time Up and Go (TUG) and Six-Minute Walk Test (6MWT), Modified Fatigue Impact Scale (MFIS), Multiple Sclerosis Quality of Life-54 Questionnaires (MSQOL-54) were measured before and after the 10-week. RESULTS: The Interleukin 17 variable significantly decreased in the Brythonic (P < 0.0001). Nevertheless, Interleukin 4 and the Interleukin 17 and 4 ratios did not significantly differ. TUG and 6MWT variables substantially differed in training groups compared to the control. In MFIS, a significant difference was observed between the training and control groups. The MSQOL-54 variable substantially differed in mental health items in the Brythonic compared to the control group and in physical health items a significant difference was observed between the training and the control groups. Notably, in all the variables except the Interleukin 4 variable, the Brythonic significantly improved the results within the group. CONCLUSION: This study concluded that engaging in any aerobic activity, even with moderate intensity, can improve some symptoms of MS such as fatigue and physical performance. Additionally, incorporating cognitive challenges into aerobic activity can cause a more significant effect, specifically on inflammatory factors.

doi.org/10.1016/j.msard.2025.106412PubMed 40409172Interventions