Brain and Behavior · Dec 2024

Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients

By Yeh EL, Yang CP, Lin SW et al.

OBJECTIVES: Migraine is a chronic, recurring, and disabling disease. Fish oil intervention was used to investigate its effects on headache symptoms and blood lipids of migraine patients. DESIGN: All subjects were collected at the Kuang Tian General Hospital from March 2020 to May 2021. Experimental group subjects took 1 g/time of fish oil (including EPA 900 mg/tablet) after breakfast and dinner. Placebo group subjects took 100% soybean oil twice daily. Before and after the test, the migraine improvement questionnaire was used to analyze headaches during attacks, dietary intake, and headache triggers. RESULTS: The average age of the 47 subjects in this study was 40.3 ± 9.2 years old, the body mass index (BMI) was 24.3 ± 6.0 kg/m². At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). Blood lipid indexes TC, LDL-C, and TG were reduced, and the frequency, duration, and pain degree of migraine. CONCLUSION: Fish oil may be used as an adjunctive therapeutic food for relieving migraine attack symptoms and blood lipids.

doi.org/10.1002/brb3.70149Open accessPubMed 39643480Interventions