Current Heart Failure Reports · Apr 15, 2024

Putting More Weight on Obesity Trials in Heart Failure

By Harrington J, Sattar N, Felker GM et al.

PURPOSE OF REVIEW: To review ongoing and planned clinical trials of weight loss among individuals with or at high risk of heart failure. RECENT FINDINGS: Intentional weight loss via semaglutide among persons with heart failure and preserved ejection fraction and obesity significantly improves weight loss and health status as assessed by the KCCQ-CSS score and is associated with improvements in 6-min walk test. Ongoing and planned trials will explore the role of intentional weight loss with treatments such as semaglutide or tirzepatide for individuals with heart failure across the entire ejection fraction spectrum.

doi.org/10.1007/s11897-024-00655-zPubMed 38619690Interventions