Oncoimmunology · Nov 14, 2022

Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

By Castoldi F, Kroemer G, Pietrocola F

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

doi.org/10.1080/2162402x.2022.2146855 Open access PubMed 36387057 Interventions