Immunity · Sep 13, 2022

Skip the buffet, for SPARC's sake

By Zhai L, Krawczyk CM

Caloric restriction (CR) reduces inflammation and the incidence of chronic diseases, thereby extending healthspan and lifespan. In this issue of Immunity, Ryu et al. (2022) propose that reduction of SPARC, a matricellular protein, during CR offers beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.

doi.org/10.1016/j.immuni.2022.08.012Open accessPubMed 36103855Interventions