Kidney International · Oct 25, 2021

Ketone bodies: back to a place in the sun

By Kume S

Ketone bodies have a strong negative image in medicine because of ketoacidosis, a life-threatening complication in diabetes. However, Fang et al. report that ketone bodies exert antisenescent effects in podocytes under diabetic conditions, via activation of the nuclear factor E2-related factor 2-related antioxidative stress pathway. With recent progression of research on longevity, the beneficial effects of ketone bodies are being clarified, and a positive image of ketone bodies is gradually beginning to develop in many research fields including nephrology.

doi.org/10.1016/j.kint.2021.07.022 Open access PubMed 34688385 Interventions