Mechanisms of Ageing and Development · Jun 12, 2021

Coenzyme Q₁₀ supplementation - In ageing and disease

By Aaseth J, Alexander J, Alehagen U

Coenzyme Q₁₀ (CoQ₁₀) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ₁₀ by a specialized cytoplasmatic-mitochondrial pathway. CoQ₁₀ deficiency can result from genetic failure or ageing. Some drugs including statins, widely used by inter alia elderly, may inhibit endogenous CoQ₁₀ synthesis. There are also chronic diseases with lower levels of CoQ₁₀ in tissues and organs. High doses of CoQ₁₀ may increase both circulating and intracellular levels, but there are conflicting results regarding bioavailability. Here, we review the current knowledge of CoQ₁₀ biosynthesis and primary and acquired CoQ₁₀ deficiency, and results from clinical trials based on CoQ₁₀ supplementation. There are indications that supplementation positively affects mitochondrial deficiency syndrome and some of the symptoms of ageing. Cardiovascular disease and inflammation appear to be alleviated by the antioxidant effect of CoQ₁₀. There is a need for further studies and well-designed clinical trials, with CoQ₁₀ in a formulation of proven bioavailability, involving a greater number of participants undergoing longer treatments in order to assess the benefits of CoQ₁₀ treatment in neurodegenerative disorders, as well as in metabolic syndrome and its complications.

doi.org/10.1016/j.mad.2021.111521 Open access PubMed 34129891 Interventions