Clinica Chimica Acta; International Journal of Clinical Chemistry · Jan 21, 2021

NAD⁺ and cardiovascular diseases

By Lin Q, Zuo W, Liu Y et al.

Nicotinamide adenine dinucleotide (NAD) plays pivotal roles in controlling many biochemical processes. 'NAD' refers to the chemical backbone irrespective of charge, whereas 'NAD⁺' and 'NADH' refers to oxidized and reduced forms, respectively. NAD⁺/NADH ratio is essential for maintaining cellular reduction-oxidation (redox) homeostasis and for modulating energy metabolism. As a sensing or consuming enzyme of the poly (ADP-ribose) polymerase 1 (PARP1), the cyclic ADP-ribose (cADPR) synthases (CD38 and CD157), and sirtuin protein deacetylases (sirtuins, SIRTs), NAD⁺ participates in several key processes in cardiovascular disease. For example, NAD⁺ protects against metabolic syndrome, heart failure, ischemia-reperfusion (IR) injury, arrhythmia and hypertension. Accordingly, the subsequent loss of NAD⁺ in aging or during stress results in altered metabolic status and potentially increased disease susceptibility. Therefore, it is essential to maintain NAD⁺ or reduce loss in the heart. This review focuses on the involvement of NAD⁺ in the pathogenesis of cardiovascular disease and explores the effects of NAD⁺ boosting strategies in cardiovascular health.

doi.org/10.1016/j.cca.2021.01.012PubMed 33485900Interventions