Current Opinion in Pulmonary Medicine · Oct 1, 2019

Prevention of osteoporosis in cystic fibrosis

By Chedevergne F, Sermet-Gaudelus I

PURPOSE OF REVIEW: The increased life span of patients with cystic fibrosis has lead to the detection of new complications. Osteopenia is present in up to 50% of adult patients with cystic fibrosis, and osteoporosis in 10-34% and can cause a difficult management problem. RECENT FINDINGS: In children, defects in bone health become apparent generally at adolescence because of suboptimall bone peak mass achievement. Malnutrition, inflammation, vitamin D and vitamin K deficiency, altered sex hormone production, glucocorticoid therapy, and physical inactivity potentiate poor bone health. SUMMARY: Monitoring bone mineral density and preventive care of osteoporosis are necessary from childhood to minimize cystic fibrosis-related bone disease in adult cystic fibrosis patients.

doi.org/10.1097/mcp.0000000000000624PubMed 31567515Interventions