Clinical Calcium · 2018
Aging-related frailty and sarcopenia. Efficacy of osteoporosis treatment drugs for frailty and sarcopenia
By Watanabe T, Matsui Y
Many of the adverse outcomes of frailty are probably mediated by sarcopenia. Unfortunately, there are currently no approved drug treatments for sarcopenia. Osteoporosis and sarcopenia are common in older age. A study on activated vitamin D revealed that muscle mass could be maintained by administering alfacalcidol to patients with osteoporosis. Bisphosphonate therapy, which is a gold standard for osteoporosis treatment, may help to maintain muscle mass.