Bulletin of Experimental Biology and Medicine · Feb 27, 2017

Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice

By Gruden MA, Davydova TV, Fomina VG et al.

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.

doi.org/10.1007/s10517-017-3632-2PubMed 28239790Interventions