Journal of Drugs in Dermatology · Nov 1, 2016
Efficacy of a Skin Condition-Adapted Solution for Xerosis and Itch Relief Associated With Aging
By Yadgar RJ, Friedman AJ
In recent decades, the stratum corneum (SC), has been recognized for its multifunctional role in maintaining the homeostasis of the human epidermal barrier. A better understanding of the SC's ability to act as its own biosensor in detecting dysfunction and integrating restorative actions can help identify the origin of certain skin conditions. A more holistic understanding of the morphological changes of the SC during the natural aging process and how it deviates in disease states can help bring about new treatment strategies. Some important recent clinical studies point to new treatments and add to the existing body of research on corneobiology. These studies offer some explanation of and validation for the various ingredients incorporated into moisturizers and barrier repair devices aimed at treating pruritus and xerosis associated with the aging skin. J Drugs Dermatol. 2016;15(suppl 11):s91-94.