Bulletin of Experimental Biology and Medicine · Jun 4, 2016

Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro

By Lin'kova NS, Drobintseva AO, Orlova OA et al.

The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy. All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging. Peptides AED and AEDG suppressed caspase-dependent apoptosis that increases during aging of cell cultures.

doi.org/10.1007/s10517-016-3370-xPubMed 27259496Interventions