Bioscience, Biotechnology, and Biochemistry · Mar 11, 2016

Glucose-induced abnormal egg-laying rate in Caenorhabditis elegans

By Teshiba E, Miyahara K, Takeya H

High glucose reduced the egg-laying rate of the nematode Caenorhabditis elegans and was dependent on serotonergic signaling. Antidiabetic drugs of the biguanide and thiazolidine classes ameliorated the detrimental effect of glucose on egg-laying rate, suggesting the possibility that this quick and easy assay system may be applicable to whole-animal screening for novel antidiabetic drugs, at least, of these classes.

doi.org/10.1080/09168451.2016.1158634PubMed 26966894Interventions