Fertility and Sterility · Nov 1, 2006

Testosterone replacement increases vasodilatory reserve in androgen-deficient female rats

By Cooper BC, Gokina NI, Osol G

Testosterone replacement leads to increased coronary pressure-induced tone and vasodilatory reserve in oophorectomized rats. The mechanisms involve changes in endothelial nitric-oxide modulation of smooth-muscle constriction and are not a result of the peripheral conversion of T to estrogen.

doi.org/10.1016/j.fertnstert.2006.06.033Open accessPubMed 17081525Interventions