Voprosy Onkologii · 2001
Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma
By Khavinson VKh, Iuzhakov VV, Kvetnoĭ IM et al.
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg). The effect lasted for two weeks after injection course. Decrease in proliferative activity was not associated with the drug's immediate cytostatic action on tumor cells. The specific mechanism of the drug's action via blood flow was shown by morphological signs of hemorrhagic necrosis of tumor and increased apoptosis of tumor cells.