Neuro Endocrinology Letters · Aug 2001
Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys
By Khavinson V, Goncharova N, Lapin B
UNLABELLED: The OBJECTIVE of this research was to investigate the regulatory effect of Epitalon on the production of melatonin and cortisol in senescent monkeys. MATERIAL AND METHODS: We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods. RESULTS: Epitalon was proven to significantly stimulate melatonin synthesis in senescent monkeys in the evening, thereby normalising the circadian rhythm of cortisol secretion.