Revista Tópicos · Nov 6, 2026

Polylaminin: A literature review of the biomolecule and its translational potential in the treatment of chronic diseases

By Dos Santos EVB, Lopes EA, Neto PVL et al.

Polylaminin has attracted scientific interest because of its potential in neural regeneration and applications in regenerative medicine. Formed by the association of molecules of laminin, an extracellular matrix protein, this structure participates in processes related to cell adhesion, organization, and differentiation. This study aimed to analyze the biomolecular properties of polylaminin and its therapeutic potential in chronic diseases, with an emphasis on neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. This is a narrative literature review conducted through searches in PubMed, the Virtual Health Library (BVS), SciELO, Google Scholar, Zenodo, and the CAPES Periodicals Portal. Portuguese and English descriptors related to polylaminin, laminin, extracellular matrix, neural regeneration, regenerative medicine, and neurodegenerative diseases were used. Materials relevant to understanding the structural, biological, and therapeutic properties of the molecule were selected, prioritizing recent publications and including pertinent classic studies. The literature analyzed presents promising experimental results, especially regarding the promotion of axonal growth and the regeneration of nervous tissue, suggesting possibilities for the development of new therapeutic strategies. However, the available evidence is still insufficient to confirm its clinical efficacy in the treatment of neurodegenerative diseases. In addition, further studies are needed to investigate its safety, stability, routes of administration, and possible adverse effects. It is concluded that polylaminin represents a promising prospect for regenerative medicine, but its therapeutic application in chronic diseases depends on further research establishing its efficacy and safety.

doi.org/10.70773/revistatopicos/793913391Open accessInterventions