Zenodo · Jun 13, 2026
Western Diet (WD) predisposes to chronic disease by at least two mechanisms
By Mamoor S
We demonstrate here that Western Diet (WD) predisposes to chronic disease by at least two mechanisms: through chronic senescence impairment involving environmentally (diet)-induced defects in interferon signaling globally, and through propagation of inflammatory signaling via excess lipid consumption. We contrast this to what is described in medicine and scientific literature as a high-fat diet (HFD). We examined total transcription in the tissues in humans following experimentally administered caloric restriction or Western Diet. Muscle biopsies of humans fed a Western Diet displayed marked activation of the obesogenic neuropeptide leptin, which was among the most significant gene expression changes transcriptome-wide, together with reduction of or silencing in a myogenic-adipogenic program featuring silencing of myogenic factor Myof6, the muscle related coil coil protein MURC, and the brown fat switch UCP3. Finally, we examine the transcriptome of healthy and obese individuals to identify and describe genes important for human metabolism induced or controlled by obesity.