Zenodo
Senescent cell elimination targeting AAT-deficient lung aging
PreprintInterventions
Abstract
Dasatinib + quercetin senolytic therapy eliminates p16INK4a+ senescent alveolar epithelial cells that secrete SASP factors (IL-6, TNF-α) promoting neutrophil elastase (ELANE) activity and reducing local SERPINA1 effectiveness through oxidative modifications at Met358 residue
The paper
MedicOath
Zenodo, 28 Apr 2026, Open access, CC0, Preprint, not peer-reviewed
