Journal Of Stem Cell Research · Oct 14, 2026
Platelet-Rich Plasma for Vulvovaginal Disorders: An Umbrella Review of Nineteen Systematic, Scoping and Narrative Reviews Published Since 2020
By Probst MA
Background: Platelet-rich plasma (PRP) is offered increasingly widely for vulvar lichen sclerosus (VLS), the genitourinary syndrome of menopause (GSM), female sexual dysfunction (FSD) and stress urinary incontinence (SUI).The number of reviews summarising this practice has grown quickly, and their consistently favourable tone is now itself used as justification for clinical adoption.Objective: To appraise, at the level of the secondary literature, what the post-2020 reviews of vulvovaginal PRP collectively establish; to reconstruct the primary-evidence layer beneath them after removing double-counted studies; and to define the minimum design and reporting standards that future trials in regenerative gynaecology must meet. Methods:We conducted an umbrella review of systematic, scoping and structured narrative reviews published from 2020 onward that addressed PRP for vulvovaginal or lower genital tract indications.Ovarian, endometrial and infertility-only reviews were excluded.Twenty-seven candidate records were retrieved and read; every extracted value was bound to the specific source page that stated it, and values that could not be confirmed on a retrieved page were recorded as not available rather than inferred.For the subset of reviews publishing an included-study list, we constructed a primary-study overlap matrix and deduplicated participants and study designs.