RECIMA21 - Revista Científica Multidisciplinar · Jun 27, 2026
Impact of hormone therapy on metabolic syndrome and quality of life in menopausal women
By Vieira VDJCL, Soares EEL, Cantuário JMDO et al.
Menopause is a natural phase of female aging marked by reduced estrogen and progesterone production, triggering metabolic changes and symptoms that can compromise women's health and quality of life. The main changes observed include increased abdominal fat, insulin resistance, dyslipidemia, and increased cardiovascular risk, factors associated with the development of metabolic syndrome. In addition, manifestations such as hot flashes, sleep disturbances, fatigue, irritability, and emotional changes significantly affect women's well-being. In this context, this study aimed to analyze the impact of hormone replacement therapy on metabolic syndrome and quality of life in menopausal women. To this end, a systematic literature review was conducted based on studies published between 2020 and 2026, in Portuguese and English, identified in national and international scientific databases. The results demonstrated that hormone replacement therapy may have positive effects on the metabolic profile, contributing to reduced insulin resistance, control of lipid levels, and decreased visceral fat. Significant improvements were also observed in vasomotor symptoms, sleep quality, psychological well-being, and sexual function, promoting better quality of life. However, treatment efficacy may vary according to individual factors, such as age, time since menopause, and clinical conditions.