Diabetes & Metabolism Journal · Nov 1, 2026
Effects of a 6-Month Intervention on Body Weight and Cardiometabolic Parameters Based on the Korean Diabetes Prevention Study
By Chon S, Yun SJ, Sang H et al.
Background: This study evaluated the 6-month effects of the Korean Diabetes Prevention Study (KDPS) interventions on body weight and cardiometabolic parameters in adults with prediabetes.Methods: Adults aged 30–70 years with body mass index ≥23 kg/m² were randomized to lifestyle modification (LSM), metformin (MET), or standard management (STM). The KDPS-LSM program combined intensive nutrition education and LSM including 10 key healthy habits with personalized counseling, targeting ≥5% weight loss in 6 months followed by long-term maintenance. Cardiometabolic parameters were assessed before and after the intervention (Trial registration: CRIS KCT0002260, NCT02981121).Results: Of 701 completers (262 STM, 222 LSM, 217 MET), all groups showed significant weight reduction (−0.7 kg STM, −2.3 kg LSM, −2.0 kg MET; P<0.001). The LSM group achieved the largest weight reduction and the highest ≥5% weight-loss rate. Glycemic indices remained largely stable in the LSM and MET groups, whereas FPG increased significantly in the STM group; a significant reduction in HbA1c was observed only in the MET group. Even modest (<5%) weight loss conferred cardiometabolic benefits, and greater loss correlated with higher adherence to LSM or higher MET exposure.Conclusion: All KDPS interventions reduced body weight after 6 months, with LSM providing the best weight outcomes and MET showing the most favorable glycemic effects.