Chinese Journal of Osteoporosis · Oct 23, 2026
Research on the regulation of osteosarcopenia by short-chain fatty acids and targeted therapeutic strategies
By 许婷
Osteosarcopenia is one of the challenges currently faced amid global population aging; it combines the symptoms of sarcopenia and osteoporosis and is associated with adverse outcomes such as falls, fractures, and functional impairment, affecting patients' quality of life and independence while also increasing the risks faced by older adults and the burden on society. In recent years, the benefits of the gut microbiota to the body have received increasing attention, and its products, short-chain fatty acids, have multiple advantages, including anti-inflammatory effects, maintenance of immune homeostasis, and regulation of metabolism. This article reviews advances in the application of short-chain fatty acids in sarcopenia and osteoporosis and explores their possible mechanisms for preventing osteosarcopenia and targeted intervention approaches, providing a reference for the prevention and treatment of osteosarcopenia.