Nursing Edição Brasileira · Aug 27, 2026

Impact of Hormone Replacement Therapy on Psychiatric Symptoms of Perimenopause

By Camacho ALT, de Lima CF, Queiroz CDA

Perimenopause represents a period of biological transition marked by intense hormonal fluctuations that significantly affect women's mental health. The decline in estrogen levels is frequently associated with the onset or exacerbation of depressive symptoms, anxiety, and irritability. This study presents a systematic review of the literature aimed at evaluating the impact of hormone replacement therapy (TRH) on reducing these psychiatric symptoms. The methodology was based on a structured search of the SciELO, LILACS, and PubMed databases, prioritizing publications from the last twenty years that addressed the correlation between hormonal support and psychological well-being. The results indicate that TRH, especially when administered transdermally, provides clear benefits in stabilizing mood during the menopausal transition, acting through the modulation of neurotransmitters such as serotonin. It is concluded that hormone therapy should be considered as an adjunctive or primary therapeutic strategy in the management of psychiatric disorders of perimenopause, with individualized assessment of the risks and benefits by a multidisciplinary team being essential.

doi.org/10.36489/nursing.2026v32i340p18888-18891Open accessInterventions