International Journal of Health Science · Jan 26, 2026

Advances in tissue engineering and 3D bioprinting for skin reconstruction

By PEREIRA ELV, Franco LPDC, Salles RCDA et al.

Skin reconstruction represents a significant challenge in clinical practice, especially in patients with large skin losses resulting from extensive burns, trauma, chronic wounds, and oncological resections.In recent decades, tissue engineering and 3D bioprinting have emerged as promising strategies to overcome the limitations of traditional skin grafts and conventional skin substitutes.These advances enable the development of bioengineered tissues that are closer to native skin, with potential for vascularization, tissue integration, and functional restoration.This article reviews the main advances in tissue engineering and 3D bioprinting applied to skin reconstruction, addressing fundamental concepts, biomaterials, cell types, technical challenges, clinical applications, and future perspectives.

doi.org/10.22533/at.ed.1595322621011 Open access Interventions