Preprint · Feb 14, 2023
Effects of physical exercise on telomere length in healthy adults: a systematic review, meta-analysis, and meta-regression (Preprint)
By Tejada-Garrido CI, Sánchez-Rodríguez JL, Varela-Rodríguez S et al.
BACKGROUND Physical exercise seems to have a beneficial effect on telomere length, however, the effects according to the type of exercise have not been studied in detail. OBJECTIVE a meta-analysis of randomized controlled trials (RCTs) was conducted to determine de effect of physical exercise in telomere length in heathy population. METHODS Data source: PUBMED, Cochrane Library, EMBASE, Web of Science and SCOPUS from inception to September 2022 were searched to identify documents. Study selection: Publications investigating the effect of physical exercise in telomere length. Data extraction: data were extracted into predesigned data extraction and tables. Risk of bias was evaluated with the Cochrane Risk Of Bias Tool (Rob 2.0 and Robins II). 9 articles met inclusion criteria. RESULTS Random-effects model analysis were used to quantify the difference in telomere length between exercise group and sham. CONCLUSIONS The findings of the current systematic review with meta-analysis suggest that high-intensity interval training seems to have a positive effect on telomere length compared to other types of exercise such as resistance training or aerobic exercise in a healthy population