Research Square · Feb 17, 2022
Effect of bilateral paravertebral nerve block on cognitive function in elderly patients undergoing radical gastrectomy for gastric cancer
By Shang Y, Qi F, Zheng Z et al.
Abstract Objective To investigate the effect of bilateral paravertebral nerve block on cognitive function in elderly patients undergoing radical gastrectomy for gastric cancer(GC). Methods One sixty elderly patients, which were 40 males and 20 females, aged 65-80 years old, undergoing radical GC surgery under general anesthesia in The First People’s Hospital of Taicang from January 2019 to December 2021 were included and randomly divided into control group (group C) and paravertebral nerve block group (group PVB).Group PVB received ultrasound-guided bilateral paravertebral nerve blocks in T8 with 0.375% ropivacaine 20 ml, and group C did not receive special treatment. Patients in both groups received total intravenous anesthesia. propofol and remifentanil dosages and intraoperative information were recorded. Results There were no statistically significant differences in general information and basic intraoperative conditions between the two groups (P > 0.05). The awareness time in group PVB was shorter than that in the C group, and the propofol and remifentanil dosage was less than that in the C group (P < 0.05). At T1 and T2, the MMSE score in group PVB was higher than that in group C, and the NSE concentration was lower than that in the C group(P < 0.05). Conclusion Preoperative application of ultrasound-guided bilateral paravertebral nerve blocks can reduce intraoperative propofol and remifentanil dosage, postoperative awareness time, and have a protective effect on postoperative cognitive function in elderly GC surgery patients.