AHA Scientific Sessions 2026 Abstract · Nov 2, 2026
Improving LDL-C Goal Attainment Through a Digital Health-Enabled Lipid Program: Early Experience from the LATTICE Consortium
By Suresh A, Kodukula SS, Baggett K et al.
Background: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide. Lipid-lowering therapies (LLT) can reduce low-density lipoprotein cholesterol (LDL-C) and ASCVD events. However, substantial gaps persist in LLT initiation and adherence, with less than 1/3 of patients achieving guideline recommendations for LDL-C goals. These gaps underscore the need for scalable, innovative implementation strategies to translate evidence-based LDL-C management into routine clinical practice. The Leading Awareness to Action through Implementation of Cardiometabolic Efforts (LATTICE) consortium was recently established to explore novel implementation science strategies that address cardiometabolic gaps in care. Purpose: The Corrie Lipids Program is a digital health-enabled initiative highlighted by the LATTICE consortium that is designed to empower patients and clinicians to rapidly improve lipid management among adults with high ASCVD risk and uncontrolled LDL-C. The program uses the Corrie smartphone app to deliver LLT medication reminders, LDL-C tracking, and multimodality education targeted to increase patient activation and adherence to lipid management. We analyzed data from the early implementation phase of this program to understand key insights surrounding digital health-enabled lipid optimization and future scalability. Methods: Patients with uncontrolled LDL-C and high ASCVD risk were enrolled at Johns Hopkins clinics (Figure). Patients were given access to the Corrie app. Baseline lab values were collected per routine care including LDL-C, lipoprotein (a) (Lp(a)), and apolipoprotein B (apoB). Follow-up LDL-C levels were collected at guideline recommended intervals, enabling early assessment of lipid trajectories and timely intensification of LLT. Results: Among the first 20 patients enrolled, at baseline mean age was 61±13 years, 55% were female, mean LDL-C was 114±46 mg/dL, mean Lp(a) was 177±176 nmol/L (53% had Lp(a)>125 nmol/L), and mean apoB was 94±32 mg/dL. At 4-6 week follow-up, the mean on-treatment LDL-C was 54±42 mg/dL and 72% met their LDL-C goal. With regards to patient engagement, 100% of patients downloaded the Corrie application. Use of the Corrie Lipids Program in routine care at Johns Hopkins was described as feasible and successful by users and clinicians. Conclusion: Early results show that high-risk patients in the Corrie Lipids Program had high levels of engagement and rapid improvement in LDL-C management. With program implementation, >70% met their LDL-C goal at 4-6 weeks, compared to national estimates of only 20-30%. Ongoing enrollment and follow-up will evaluate sustained engagement and lipid goal attainment to support scalability and broader dissemination across health systems.