AHA Scientific Sessions 2026 Abstract · Nov 2, 2026
Effect of Catheter-Based Renal Denervation on Central Hemodynamics in Chinese Patients with Uncontrolled Hypertension
By Zhang Z, Chen X
Aims: Our study aimed to investigate the effect of renal denervation (RDN) on central hemodynamics in Chinese patients with uncontrolled hypertension. Methods: This cohort study included a subset of participants from the Iberis-HTN and Netrod TM -HTN trials previously conducted at our center. Eligible patients were randomly assigned to undergo either radiofrequency RDN or a sham procedure. Parameters of central hemodynamics and carotid-femoral pulse wave velocity (cf-PWV) were measured using a dedicated SphygmoCor device at both baseline and 6 months after RDN. Results: The reductions in central systolic blood pressure (BP), central pulse pressure, end systolic pressure, and mean pressure during both systole and diastole from baseline to 6 months were significantly greater in the RDN group compared to the sham group (all P < 0.05). However, the difference in central diastolic BP reduction between the two groups approached statistical significance (P = 0.068). Furthermore, the reduction in the forward wave P1 height was more pronounced in the RDN group than in the sham group (adjusted between-group difference: -4.1±1.9 mmHg, P = 0.039). No significant between-group differences were observed in the changes of reflected wave parameters (P >0.05). The changes in cf-PWV between groups did not differ significantly from baseline to 6 months (P = 0.727). Conclusion: Catheter-based RDN effectively reduced central arterial pressure, primarily through a decrease in forward wave intensity during early systole, and mitigated cardiac afterload without significantly affecting reflected wave intensity or aortic stiffness.