medRxiv · Mar 22, 2022
In the pursuit of longevity: anti-aging substances, nanotechnological preparations, and emerging approaches
By Giannouli E, Karalis VD
Objectives: To summarize information on anti-aging substances and nanotechnology formulations against aging and to unveil emerging anti-aging approaches like gene therapy, stem cells, monoclonal antibodies, and future trends. Methods: A systematic literature search was conducted through May 10, 2021. Eligibility criteria were articles in English relevant to the aim of this review. Results: Anti-aging substances like coenzyme Q10, curcumin, ginsenoside Rg1, bioidentical hormones, and geroprotectants, can help to slow the aging process. Nano-delivery of anti-aging substances are novel approaches able to delay aging. Cryogenic sleep, therapeutic hypothermia, and caloric restriction are promising interventions that may one day grant humans biological immortality. Discussion: The ability to target basic maturation mechanisms, such as responses to oxidative damage, inflammation, irritation, and senescence associated with multiple concurrent deficits, is the most important feature. Nanocarriers to transport bioactive compounds have been shown to improve their stability, increase intestinal absorption, and prolong their circulation time.